Gold ions released from metallic gold in living organisms reduce inflammation and improve regeneration after focal brain injury
The authors have shown that implants of pure gold release gold ions that are absorbed by cells near the implant and do not spread in the body. They “hypothesize that metallic gold could reduce local neuroinflammation in a safe way”. The “bio-release” of gold ions from pure gold requires the presence of macrophages and depends on their number and activity.
The authors injected gold particles of 20–45
 m into the neocortex of mice and then generated a cryo-injury. From the comparison of the cryo-lesions without and with preceding gold treatment the authors conclude that bio-released gold ions “possess pronounced anti-inflammatory and neuron-protective capacities in the brain”. They “suggest that metallic gold has clinical potential”.
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